HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1503094Generated: October 31, 2026
Sodium Carbonate → Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate
https://huagongshe.com/reaction/1503094
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2-(2-Bromophenylthio)-2-methylpropanoate | HCID 42205078 | — |
| Reactant | (6-Cyclopropylpyridin-3-yl)boronic acid | HCID 53338917 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate | HCID 54764233 | — |
Reaction Steps
A mixture of 2-(2-bromophenylthio)-2-methylpropanoate (1 eq), 6-cyclopropylpyridin-3-ylboronic acid (1 eq), aqueous sodium carbonate solution (2 M, 4 eq), and Pd(PPh3)4 (0.05 eq) in dioxane is degassed. The mixture is sealed, heated at 80° C., washed with water, extracted with ethyl acetate, dried (MgSO4), concentrated and purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09212135B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-3d4bb93312c04d8f83f445f70242ea35 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
