HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1503107Generated: October 30, 2026
Thionyl Chloride → (4'-Chloro-4-methylbiphenyl-3-yl)acetyl chloride
https://huagongshe.com/reaction/1503107
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4'-Chloro-4-methylbiphenyl-3-yl)acetic acid | HCID 66707678 | — |
| Product | (4'-Chloro-4-methylbiphenyl-3-yl)acetyl chloride | HCID 23390525 | — |
Reaction Steps
5.00 g (19.18 mmol) (4′-chloro-4-methylbiphenyl-3-yl)acetic acid (EP 2029531 A1 and US 2009/298828 A1) were dissolved in 36.51 g (306.84 mmol) of thionyl chloride. The reaction mixture was stirred at 80° C. for four hours and then concentrated under reduced pressure. Drying under fine vacuum gave 5.4 g (100% of theory) of the title compound as a brownish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09212140B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-3e526f2473d34378be51fe9691ad747c |
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| Source note | uspto-grants-2015_12 |
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