L-(+)-Cysteine → HCID 89483261, compound

Participants

Reaction Steps

In the same manner as in Reference Example 2, L-2-methylthiazolidine-2,4-dicarboxylic acid 2-methyl ester was synthesized from L-cysteine and pyruvic acid methyl ester, and the compound was subjected to acetylation with acetyl chloride in the presence of potassium carbonate to give N-acetyl-2-methylthiazolidine-2,4-dicarboxylic acid 2-methyl ester (with the ratio of cis form:trans form of about 44:56 as confirmed by NMR) as a white solid (80.2%). 1H-NMR (DMSO-d6,400 MHz): δ;

Provenance & Evidence