Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | L-(+)-Cysteine | HCID 5862 | — |
| Reactant | (2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 3037556 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 355961 | HCID 355961 | 83% |
Reaction Steps
Under an argon atmosphere, L-cysteine (2.42 g, 20.0 mmol), D-galactose (3.60 g, 20.0 mmol), and pyridine (0.40 ml, 5.0 mmol) were added to water (340 ml), and the solution was heated at 65° C. for 1 hour, and left standing at room temperature for 2 hours. The precipitated solid was collected by filtration, and dried under reduced pressure to give 2-(1,2,3,4,5-pentahydroxypentyl)thiazolidine-4-carboxylic acid (4.70 g) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09212154B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-5de79ce6490141caa6596b0794b5bcf4 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
