反应详情

A mixture of 10% palladium-carbon (280 mg), ethanol (25 mL) and 3,4-bis(benzyloxy)-6-[(E)-2-(3,5-difluorophenyl)vinyl]pyridazine (710 mg) was stirred under a hydrogen atmosphere at room temperature for 1 hr. The catalyst was filtered off through celite, and the filtrate was concentrated under reduced pressure. To the obtained residue was added diethyl ether and the obtained solid was dried under reduced pressure to give 6-[2-(3,5-difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one (140 mg).

1. filtrationThe catalyst was filtered off through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionTo the obtained residue was added diethyl ether
4. customthe obtained solid was dried under reduced pressure