Ethyl 2-(3,4-dichlorobenzyl)-3-oxobutanoate → HCID 178423488, compound

HRID 1503231Notes

Reaction equation

HRID 1503231 reaction equation
[NH:1]([C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=2[N:4]=1)[NH2:2].[C:13]([CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([Cl:30])[CH:24]=1)[C:17](OCC)=[O:18])(=O)[CH3:14]>>[Cl:30][C:25]1[CH:24]=[C:23]([CH2:22][C:16]2[C:13]([CH3:14])=[N:2][N:1]([C:3]3[NH:7][C:6]4[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=4[N:4]=3)[C:17]=2[OH:18])[CH:28]=[CH:27][C:26]=1[Cl:29]

Participants

3

Reactant 2

HCID 67402529Ethyl 2-(3,4-dichlorobenzyl)-3-oxobutanoateHCID 178423496HCID 178423496, compound

Product 1

HCID 178423488HCID 178423488, compound

Procedure

Using 2-hydrazino-5-methyl-1H-benzimidazole (4) obtained in Example 1, step 3 and ethyl 2-acetyl-3-(3,4-dichlorophenyl)propanoate (35), and by a method similar to that in Example 1, step 4, 4-[(3,4-dichlorophenyl)methyl]-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol (36) was obtained.

Sources & evidence

ORD record
ord-afa4044400994a19b8065d5f97c55095
Source dataset
uspto-grants-2015_12
Patent number
US09212169B2

Reaction notes

Loading…