Ethyl 2-acetyl-3-[(1,1-dimethylethyl)phenyl]propanoate → HCID 178423486, compound

HRID 1503233Notes

Reaction equation

HRID 1503233 reaction equation
[NH:1]([C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=2[N:4]=1)[NH2:2].[C:13]([CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]([CH3:32])([CH3:31])[CH3:30])[C:17](OCC)=[O:18])(=O)[CH3:14]>>[CH3:32][C:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[CH2:22][C:16]1[C:13]([CH3:14])=[N:2][N:1]([C:3]2[NH:7][C:6]3[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=3[N:4]=2)[C:17]=1[OH:18])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 117777387Ethyl 2-acetyl-3-[(1,1-dimethylethyl)phenyl]propanoateHCID 178423496HCID 178423496, compound

Product 1

HCID 178423486HCID 178423486, compound

Procedure

Using 2-hydrazino-5-methyl-1H-benzimidazole (4) obtained in Example 1, step 3 and ethyl 2-acetyl-3-[(1,1-dimethylethyl)phenyl]propanoate (41), and by a method similar to that in Example 1, step 4, 4-[[(1,1-dimethylethyl)phenyl]methyl]-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol (42) was obtained.

Sources & evidence

ORD record
ord-3b28219f77164b84a291b6f210f90498
Source dataset
uspto-grants-2015_12
Patent number
US09212169B2

Reaction notes

Loading…