反应详情

6-Hydrazino-N-[4-(trifluoromethyl)phenyl]nicotinamide (0.31 g) and ethyl 2-acetamido-3-oxobutanoate (0.24 g) were suspended in ethanol (25 mL), and the suspension was heated to reflux for 23 hours. The reaction solution was cooled to room temperature, and the obtained solid was collected by filtration and washed with ethanol. The solid was dried under reduced pressure to obtain the title compound (0.20 g) as a white solid (yield: 46%).

1. temperaturethe suspension was heated
2. temperatureto reflux for 23 hours
3. filtrationthe obtained solid was collected by filtration
4. washwashed with ethanol
5. customThe solid was dried under reduced pressure