Ethyl 2-acetamido-3-oxobutanoate → HCID 71765861, 화합물

HRID 1503242노트

반응식

HRID 1503242 반응식
[NH:1]([C:3]1[CH:21]=[CH:20][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[O:8])=[CH:5][N:4]=1)[NH2:2].[C:22]([NH:25][CH:26]([C:32](=O)[CH3:33])[C:27](OCC)=[O:28])(=[O:24])[CH3:23]>C(O)C>[C:22]([NH:25][C:26]1[C:27](=[O:28])[N:1]([C:3]2[CH:21]=[CH:20][C:6]([C:7]([NH:9][C:10]3[CH:11]=[CH:12][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:14][CH:15]=3)=[O:8])=[CH:5][N:4]=2)[NH:2][C:32]=1[CH3:33])(=[O:24])[CH3:23]

참가 물질

4

반응물 2

HCID 224840Ethyl 2-acetamido-3-oxobutanoateHCID 62237424HCID 62237424, 화합물

생성물 1

HCID 71765861HCID 71765861, 화합물수율 46%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6-Hydrazino-N-[4-(trifluoromethyl)phenyl]nicotinamide (0.31 g) and ethyl 2-acetamido-3-oxobutanoate (0.24 g) were suspended in ethanol (25 mL), and the suspension was heated to reflux for 23 hours. The reaction solution was cooled to room temperature, and the obtained solid was collected by filtration and washed with ethanol. The solid was dried under reduced pressure to obtain the title compound (0.20 g) as a white solid (yield: 46%).

후처리

  1. temperaturethe suspension was heated
  2. temperatureto reflux for 23 hours
  3. filtrationthe obtained solid was collected by filtration
  4. washwashed with ethanol
  5. customThe solid was dried under reduced pressure

출처 및 근거

ORD 기록
ord-2cab87a3c0214224adadc1612c0cd4df
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212170B2

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