2-Pyrazinecarboxylic acid → HCID 117702478, compound

Participants

Reaction Steps

Examples 52 and 53 of table 1, N-((1R,5S)-5-((2-methylthiazol-4-yl)ethynyl)bicyclo[3.2.1]octan-1-yl)pyrazine-2-carboxamide and N-((1S,5R)-5-((2-methylthiazol-4-yl)ethynyl)bicyclo[3.2.1]octan-1-yl)pyrazine-2-carboxamide, were prepared analogously to Example 14 from commerically available pyrazine-2-carboxylic acid and intermediate 7-A or 7-B at ˜0.1 mmol reaction scale, respectively. 1H NMR (500 MHz, CDCl3): δ 9.38 (d, J=1.4 Hz, 1H), 8.74 (d, J=2.5 Hz, 1H), 8.50 (m, 1H), 7.90 (s, 1H), 7.18 (s, 1H), 2.69 (s, 3H), 2.49 (m, 1H), 2.29-2.13 (m, 3H), 2.02 (m, 2H), 1.91 (d, J=8.4 Hz, 1H), 1.86-1.71 (m, 5H); ESI-MS m/z: 353 (M+H)+.

Provenance & Evidence