Sodium Hydroxide → HCID 54767998, compound

Participants

Reaction Conditions

Reaction Steps

2-tert-Butoxycarbonylamino-3-[6-(4-phenoxyphenyl)-1H-indol-3-yl]-propionic acid (17) was prepared as follows: A mixture of compound 16 (0.1 g in 4 mL MeOH) and NaOH (0.5N aqueous, 0.5 mL) was shaken at 30° C. for 24 hours. The solvent was removed under vacuum. The residue was suspended in CHCl3 (20 mL), neutralized with 0.5N HCl to ˜pH 2, and concentrated to get compound 17 as a white solid (50 mg, 53%): 1H-NMR (400 MHz, CD3OD/CDCl3 3/1) δ: 7.8-7.84 (m, 3H), 7.75 (s, 1H), 747-7.57 (m, 3H), 7.2-7.32 (m, 6H), 4.61-4.65 (m, 1H), 3.51-3.55 (m, 1H), 3.31-3.37 (m, 1H), 1.43-1.6 (m, 9H); LC/MS: m/z=495.6 [M+Na+]+ (Calc: 472.5).

Provenance & Evidence