HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Bazedoxifene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Azepane | HCID 8119 | — |
| Reactant | bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole | HCID 131734316 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Bazedoxifene | HCID 154257 | — |
Reaction Steps
European Patent Application No. 0802183 describes a synthesis of bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole is reacted with azepan, under suitable reaction conditions, followed by deprotection to yield bazedoxifene, which on subsequent treatment with acetone and acetic acid gives bazedoxifene acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212172B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-30e213a5c70c49b3815a389b696eeaac |
| Source note | uspto-grants-2015_12 |