Bazedoxifene HCl → Bazedoxifene

Participants

Reaction Conditions

Reaction Steps

Bazedoxifene hydrochloride (1 g) and dimethylsulfoxide (10 mL) are mixed and heated to 60-70° C. to produce a clear solution, followed by filtration. To the filtrate, toluene (50 mL), morpholine (1 mL), and water (30 mL) are added and the mixture is stirred at room temperature for 12-24 hours. The solid so formed is collected by filtration, washed with toluene (5 mL), water (5 mL) and dried under vacuum below 80° C. for about 7 hours to afford 800 mg of crystalline bazedoxifene free base Form A.

Provenance & Evidence