Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl methyl ether → Bazedoxifene Acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl methyl ether | HCID 15413 | — |
| 반응물 | Bazedoxifene | HCID 154257 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Bazedoxifene Acetate | HCID 154256 | — |
반응 단계
Bazedoxifene free base (400 mg) and methyl tert-butyl ether (30 mL) are mixed and stirred for about 10 minutes. Acetic acid (0.17 g) is added slowly through a dropper and the mixture is stirred overnight for solid formation. The solid is collected by filtration to afford 250 mg of crystalline bazedoxifene acetate Form D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09212172B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-b6ac894438f44dbcbe6c1b754deae012 |
| 출처 메모 | uspto-grants-2015_12 |