HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Bazedoxifene Acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Bazedoxifene | HCID 154257 | — |
| Product | Bazedoxifene Acetate | HCID 154256 | 44.3% |
Reaction Steps
Bazedoxifene free base (400 mg) and toluene (30 mL) are mixed and stirred for about 10 minutes. Acetic acid (0.17 g) is added slowly through a dropper and the mixture stirred overnight for solid formation. The solid is collected by filtration to afford 200 mg of crystalline bazedoxifene acetate Form D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212172B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-694e210bcd174ae888593a0710253c2e |
| Source note | uspto-grants-2015_12 |