Acetic Acid → Bazedoxifene Acetate

Participants

Reaction Conditions

Reaction Steps

Acetic acid (0.764 g) is charged in a mixture of ethyl acetate (35 mL) and ethanol (15 mL) and reaction mixture is cooled to −5 to −10° C. In a separate flask, crystalline bazedoxifene free base is dissolved in mixture of ethyl acetate (35 mL) and ethanol (15 mL) and the said mixture is added to the previous reaction mixture of acetic acid at −5 to −10° C. The mixture is stirred at same temperature for about 24 hours. The solid is collected by filtration and dried under vacuum at about 50° C. for 3 hours to afford the title compound.

Provenance & Evidence