Carbon Dioxide → Benzeneacetic acid, 4-bromo-

HRID 1503368Notes

Reaction equation

HRID 1503368 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C(O)=O)[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.C(=O)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 280Carbon DioxideHCID 21866616Propanedioic acid, 2-(4-bromophenyl)-

Product 1

HCID 74654Benzeneacetic acid, 4-bromo-Yield 1,099.1%

Procedure

2-(4-Bromophenyl)malonic acid (36 g, 11 mmol) was heated at 165° C. until evolution of CO2. the production was crystallized from petrol ether to give 2-(4-bromophenyl)acetic acid (26 g, 87%).

Workup

  1. customthe production was crystallized from petrol ether

Sources & evidence

ORD record
ord-adb9b367a7b846349368b9286a46743a
Source dataset
uspto-grants-2015_12
Patent number
US09212153B2

Reaction notes

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