HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 6'-Bromospiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6'-bromo-4,4-difluorospiro[cyclohexane-1,2'-inden]-1'(3'H)-one | HCID 58197272 | — |
| Product | 6'-Bromospiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione | HCID 58197205 | 53% |
Reaction Steps
According to a similar synthesis of compound 344, compound 5 (100 mg, 0.26 mmol) was alkylated with compound 2 (159 mg, 1.04 mmol) in the presence of Cs2CO3 (339 mg, 1.04 mmol) to give compound 4 (73 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212153B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-d93a0ca025284239b3548690aeec1fe8 |
| Source note | uspto-grants-2015_12 |