Acetonitrile → HCID 67043662, compound

Participants

Role	Name	HCID	Charge
Reactant	Acetonitrile	HCID 6342	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-Bromo-1,1,1-trifluoropropane	HCID 2725114	—
Reactant	N-(5'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-3'(1'H)-ylidene)-2-(trimethylsilyl)ethanesulfonamide	HCID 67043529	—
Product	HCID 67043662	HCID 67043662	80%

Reaction Steps

To a solution of compound 8 (100 mg, 0.27 mmol) in CH3CN (5 mL) was added K2CO3 (74 mg, 0.54 mmol). After addition, the resulting mixture was stirred at room temperature for 10 min. Then 3-bromo-1,1,1-trifluoro-propane (47.8 mg, 0.27 mmol) in CH3CN (5 mL) was added dropwise via a syringe with stirring. The mixture was stirred at 60° C. overnight, and then the mixture was filtered off, the filtrate was concentrated to give compound 9 (97 mg, 80%) as a white solid, which was used for the next step directly without purification. LC-MS tR=1.392 min in 2 min chromatography, MS (ESI) m/z 467.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09212153B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-72b45fa37cef4e4f9d5e01cae519fc9a
Source note	uspto-grants-2015_12