HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → HCID 59174316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 59174529 | HCID 59174529 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 59174316 | HCID 59174316 | — |
Reaction Steps
Acid 4 was directly mixed with 4-methoxybenzylamine (1.55 g, 11.3 mmol), TBTU (5.4 g, 16.8 mmol) and DIEA (2.4 mL, 13.4 mmol) in 100 mL MeCN at room temperature. The reaction mixture was run overnight to give 6 as a white solid (4.2 g, 8.5 mmol) after flash chromatography (EtOAc-hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212181B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-67b2d94ed47343879e9f37a701f30c04 |
| Source note | uspto-grants-2015_12 |