HCID 18783862, compound → tert-Butyl 4-[4-amino-2-(trifluoromethyl)phenyl]piperazine-1-carboxylate

HRID 1503861Notes

Reaction equation

HRID 1503861 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]2)=[C:6]([C:23]([F:26])([F:25])[F:24])[CH:5]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:17])[CH2:12][CH2:11]2)=[C:6]([C:23]([F:25])([F:26])[F:24])[CH:5]=1

Participants

4

Reactant 1

HCID 18783862HCID 18783862, compound

Product 1

HCID 18007750tert-Butyl 4-[4-amino-2-(trifluoromethyl)phenyl]piperazine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product of Example 44A (1 g, 2.7 mmol) in methanol (30 mL) was added Raney Nickel (100 mg) and the mixture stirred under nitrogen for 16 hours. The catalyst was filtered off and the solvent concentrated to give the title compound which was used in the next reaction without further purification. MS: 346 (M+H+).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe solvent concentrated

Sources & evidence

ORD record
ord-3fda5010f3534812b0df622ecc12c5c5
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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