Tert-butyl 4-(4-(dibenzylamino)-3-(trifluoromethoxy)phenyl)piperazine-1-carboxylate → Tert-butyl 4-(4-amino-3-(trifluoromethoxy)phenyl)piperazine-1-carboxylate

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Reaction Steps

To a solution of the product of EXAMPLE 45B (8.98 g, 16.63 mmol) in methanol (100 mL) was added 10% palladium on carbon (900 mg) and the mixture was stirred at ambient temperature under hydrogen for 5 hours. The catalyst was filtered off and the filtrate was concentrated to give the title compound. MS: 362 (M+H+).

Provenance & Evidence