HCID 86720563, compound → HCID 70565510, compound

HRID 1503868Notes

Reaction equation

HRID 1503868 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][N:15]3[CH2:18][CH2:19][CH2:20][CH:14]3[CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CO.[Ni]>[CH2:13]1[N:12]([C:5]2[CH:6]=[CH:7][C:8]([NH2:9])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:17][CH2:16][N:15]2[CH2:18][CH2:19][CH2:20][CH:14]12

Participants

4

Reactant 1

HCID 86720563HCID 86720563, compound

Product 1

HCID 70565510HCID 70565510, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a suspension of the product of Example 47A (1.58 g, 5.68 mmol) in methanol (100 mL) was added Raney-Ni (158 mg) and the mixture was stirred at ambient temperature under hydrogen for 4 hours. The catalyst was filtered off and the filtrate was concentrated to give the title compound, which was used in the next step without further purification. MS: 248 (M+H+).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-94456fd9f1b049d89920a9ada56badef
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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