Ammonia → HCID 86725416, compound

Participants

Reaction Steps

A solution of the product of Example 59A (450 mg, 0.88 mmol) and 25% ammonia solution (1 mL) in dioxane (10 mL) was heated in a sealed tube at 100° C. for 16 hours. After cooling and concentration, the residue was purified by flash chromatography on silica gel eluting with 30:1 dichloromethane:methanol to give the title compound. MS: 493 (M+H+).

Provenance & Evidence