HCID 86725417, compound → HCID 86725419, compound

HRID 1503887Notes

Reaction equation

HRID 1503887 reaction equation
[C:1]([O:5][C:6]([N:8]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH:16]=2)=[CH:11][C:10]=1[Cl:28])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[C:1]([O:5][C:6]([N:8]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:22])[CH2:17][CH2:16]2)=[CH:11][C:10]=1[Cl:28])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 86725417HCID 86725417, compound

Product 1

HCID 86725419HCID 86725419, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of the product of Example 60B (4.39 g, 10.7 mmol) and 10% palladium on carbon in methanol (100 mL) was stirred under hydrogen at ambient temperature for 4 hours. The mixture was filtered through diatomaceous earth and concentrated. The crude title compound was used in the next step without further purification.

Workup

  1. filtrationThe mixture was filtered through diatomaceous earth
  2. concentrationconcentrated
  3. customThe crude title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-f5c07fdd710b4730b39f5983a7d89f82
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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