tert-Butanol → (2-[[(4-Isocyanato-4-methylcyclohexyl)oxy]methoxy]ethyl)trimethylsilane
Reaction equation
C[C:2]1([C:17](O)=O)[CH2:7][CH2:6][CH:5]([O:8][CH2:9][O:10][CH2:11][CH2:12][Si:13]([CH3:16])([CH3:15])[CH3:14])[CH2:4][CH2:3]1.C1C=CC(P([N:34]=[N+]=[N-])(C2C=CC=CC=2)=O)=CC=1.[C:37]([OH:41])(C)(C)C>>[N:34]([C:2]1([CH3:17])[CH2:3][CH2:4][CH:5]([O:8][CH2:9][O:10][CH2:11][CH2:12][Si:13]([CH3:14])([CH3:15])[CH3:16])[CH2:6][CH2:7]1)=[C:37]=[O:41]Participants
Procedure
To a solution of 1-methyl-4-[[2-(trimethylsilyl)ethoxy]methoxy]cyclohexane-1-carboxylic acid (3.1 g, 10.75 mmol, 1.00 equiv) in tert-butanol (40 mL) was added DPPA (5.33 g, 19.37 mmol, 1.80 equiv) and TEA (3.28 g, 32.41 mmol, 3.02 equiv) at room temperature. The resulting solution was heated to reflux overnight and cooled down to room temperature. The reaction was quenched with water and extracted with 3×100 mL of ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1/100) to give (2-[[(4-isocyanato-4-methylcyclohexyl)oxy]methoxy]ethyl)trimethylsilane (1.5 g, 49%) as a colorless oil.
Workup
- temperatureThe resulting solution was heated
- temperatureto reflux overnight
- customThe reaction was quenched with water
- extractionextracted with 3×100 mL of ethyl acetate
- washThe combined organic layers were washed with brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-97a8cb3ec774448186a7a629cdbd0600
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09212190B2
Reaction notes
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