Sodium borohydride → HCID 66960443, compound

HRID 1504133Notes

Reaction equation

HRID 1504133 reaction equation
[BH4-].[Na+].[CH2:3]([N:5]1[C:11](=[O:12])[C:10]([CH3:14])([CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7]2[CH:17]=[C:18]([CH:21]=O)[CH:19]=[CH:20][C:6]1=2)[CH3:4].[NH2:23][CH2:24][CH2:25][N:26]1[CH:31]=[CH:30][C:29]2[O:32][C:33]([CH3:35])=[CH:34][C:28]=2[C:27]1=[O:36]>CO>[CH2:3]([N:5]1[C:11](=[O:12])[C:10]([CH3:14])([CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7]2[CH:17]=[C:18]([CH2:21][NH:23][CH2:24][CH2:25][N:26]3[CH:31]=[CH:30][C:29]4[O:32][C:33]([CH3:35])=[CH:34][C:28]=4[C:27]3=[O:36])[CH:19]=[CH:20][C:6]1=2)[CH3:4]

Participants

5

Reactant 3

HCID 4311764Sodium borohydrideHCID 66960461HCID 66960461, compoundHCID 866704761-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbaldehyde

Product 1

HCID 66960443HCID 66960443, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium borohydride(0.15 g) was added to a methanol solution (150 ml) of 1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbaldehyde(1.1 g) and 5-(2-aminoethyl)-2-methyl-5H-furo[3,2-c]pyridin-4-one(1.0 g), and the mixture was stirred at room temperature overnight. The reaction liquid was filtered to remove insoluble matter, and the filtrate was condensed under reduced pressure.

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. customto remove insoluble matter
  4. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-06c5bf92868347228e0c544f7913d560
Source dataset
uspto-grants-2015_12
Patent number
US09212187B2

Reaction notes

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