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A 1.0M boron tribromide/dichloromethane solution(8.5 ml) was added at 0° C. to a dichloromethane solution (50 ml) of 6-methoxy-2H-isoquinolin-1-one(1.0 g). The mixture was stirred at room temperature overnight. Water and methanol were added to the reaction mixture and extraction was carried out with a dichloromethane/methanol mixed solvent (dichloromethane:methanol=10:1). The organic layer was dried with anhydrous sodium sulfate, followed by condensation to dryness under reduced pressure, thereby obtaining the title compound(0.4 g) as a pale yellow solid.

1. dry with materialThe organic layer was dried with anhydrous sodium sulfate
2. customfollowed by condensation to dryness under reduced pressure