反应详情

A 2N-hydrogen chloride methanol solution(1.2 ml) was added to a methanol solution (4 ml) of (2-pyridin-3-ylethyl)pyridin-4-ylmethyl-[3-(tetrahydropyran-2-yloxy)propyl]amine(236 mg). The mixture was stirred at room temperature overnight. A 2N-hydrogen chloride methanol solution(0.5 ml) was added thereto, and the mixture was further stirred at 50° C. for 3 hours. Triethylamine(0.64 ml) was added to the reaction mixture, and the mixture was condensed under reduced pressure. The residue was purified by basic silica gel column chromatography (dichloromethane). The purified product was condensed under reduced pressure to give the title compound(186.3 mg) as an orange oily matter.

1. stirringthe mixture was further stirred at 50° C. for 3 hours
2. customcondensed under reduced pressure
3. customThe residue was purified by basic silica gel column chromatography (dichloromethane)
4. customcondensed under reduced pressure