Methyl iodide → 5-Methoxy-3-methylbenzofuran

HRID 1504260Notes

Reaction equation

[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[CH3:12]I>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]2[O:4][CH:3]=[C:2]([CH3:1])[C:6]=2[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 135425263-Methyl-1-benzofuran-5-ol

Product 1

HCID 131569985-Methoxy-3-methylbenzofuran

Procedure

5-Methoxy-3-methyl-benzofuran was prepared via methylation of 3-methyl-benzofuran-5-ol (Structure I) (prepared as above in EXAMPLEs I-III) using methyl iodide (MeI).

Sources & evidence

ORD record: ord-05105d3d376449dc8da5739344a04dc4
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09212336B2

Reaction notes

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