HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-chloro-5-(trifluoromethyl)aniline → N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-chloro-5-(trifluoromethyl)aniline | HCID 14099398 | — |
| Reactant | 2-Fluoropyridine-5-carbonyl chloride | HCID 14623602 | — |
| Catalyst | Dimethylacetamide | HCID 31374 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide | HCID 87422108 | — |
Reaction Steps
To a solution of 5-amino-2-bromo-4-chlorobenzotrifluoride (466 mg, 1.70 mmol) dissolved in DCM (1 mL) was slowly added a solution of 2-fluoropyridine-5-carbonyl chloride (270 mg, 1.70 mmol) in DCM (1 mL). A few drops of DMA were added and the reaction mixture was concentrated to form N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide as a purple solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212168B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c21fcc794d2d4027a7fc7feeb619f3b0 |
| Source note | uspto-grants-2015_12 |