Trifluoromethanesulfonic acid → HCID 117737018, compound

Participants

Reaction Steps

To a solution of 1-(4-bromo-2-(cyanomethoxy)-5-fluorophenyl)-N-(isoxazol-3-yl)-N-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide (0.80 g, 1.251 mmol) in DCM (12.51 ml) at room temperature was added trifluoromethanesulfonic acid (0.333 ml, 3.75 mmol). The resulting solution was stirred for 20 minutes and LCMS indicated that the reaction was complete. The reaction mixture was concentrated and loaded directly onto an silica column and purified by ISCO MPLC (100% heptanes to 75% 3:1 EtOAc:EtOH). The product eluted at 75% 3:1 EtOAc:EtOH. m/z (ESI) 522.9 (M+1)+.

Provenance & Evidence