HCID 117737276, compound → HCID 117736967, compound

Participants

Reaction Steps

A mixture of 6-(benzylthio)-1-(4′-chloro-2-fluoro-5-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (1.43 g, 2.76 mmol), and manganese dioxide (0.095 ml, 5.51 mmol) in DMF (13.78 ml) was stirred at room temperature for 4 hour. The reaction mixture was filtered through Celite, washed with methanol and the solvent was removed. The residue was purified using Biotage, eluting with a 0-50% ethyl acetate in hexane gradient, to afford 6-(benzylthio)-1-(4′-chloro-2-fluoro-5-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)quinoxalin-2(1H)-one (0.897 g, 1.735 mmol, 63.0% yield). m/z (ESI) 518.2 (M+H)+.

Provenance & Evidence