HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 6-(benzylthio)-1-(4-bromo-5-chloro-2-methoxyphenyl)-4-methylquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | (Z)-ethyl 3-(5-(benzylthio)-2-((4-bromo-5-chloro-2-methoxyphenyl)amino)phenyl)but-2-enoate | HCID 131734327 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(benzylthio)-1-(4-bromo-5-chloro-2-methoxyphenyl)-4-methylquinolin-2(1H)-one | HCID 117737077 | — |
Reaction Steps
The crude residue from step 3 was dissolved in 6 mL THF, was treated with potassium tert-butoxide 1N in THF (3.05 ml, 3.05 mmol) and was heated to reflux for 20 minutes. The reaction mixture was then concentrated. The crude residue was used in the next step without purification. m/z (ESI) 502.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212182B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-417b2098d07449288a2fbb83a056af65 |
| Source note | uspto-grants-2015_12 |