Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | (E)-Ethyl 3-(2-amino-5-(benzylthio)phenyl)acrylate | HCID 117740420 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 131734329 | HCID 131734329 | — |
Reaction Steps
The crude residue from the previous step was dissolved in 18 mL dioxane and was treated with xantphos (0.945 g, 1.633 mmol), pd2(dba)3 (0.374 g, 0.408 mmol), potassium phosphate (13.86 g, 65.3 mmol), and (E)-ethyl 3-(2-amino-5-(benzylthio)phenyl)acrylate (5.12 g, 16.33 mmol) and was heated to 100° C. overnight. The reaction mixture was then diluted with DCM and was washed with saturated NH4Cl solution. The organics were dried over MgSO4 and concentrated. The crude residue was used in the following step without purification. m/z (ESI) 464.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09212182B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-162e16b47ab34bdeadd66d6d45ad29b4 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
