Cyclobutanol → HCID 80873882, compound

HRID 1504559Notes

Reaction equation

HRID 1504559 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([NH2:12])[CH:7]=2)[CH2:3][CH2:2]1.C1(O)CCC1>>[CH:4]1([O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([NH2:12])[CH:7]=2)[CH2:2][CH2:3][CH2:1]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 80864926HCID 80864926, compound

Product 1

HCID 80873882HCID 80873882, compoundYield 91%

Procedure

This was prepared in a manner analogous to 6-(cyclopropylmethoxy)pyrimidin-4-amine, where cyclobutanol was used as the alcohol. 6-cyclobutoxypyrimidin-4-amine (0.231 g, 1.398 mmol, 91% yield) was obtained as a white solid. m/z (ESI) 166.2 (M+H)+.

Sources & evidence

ORD record
ord-64b06342e26d4486af15209309fb4580
Source dataset
uspto-grants-2015_12
Patent number
US09212182B2

Reaction notes

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