Diisopropylethylamine → HCID 86730052, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 6-(4-hydroxypiperidin-1-yl)nicotinamide (3.32 g, 15 mmol) in pyridine (10 mL) was added DIPEA (3.87 g, 30.0 mmol) and 4-nitrophenyl carbonochloridate (6.03 g, 30 mmol). The resulting mixture was stirred at 30° C. for 2 h before it was concentrated under reduced pressure to afford the crude product. The residue was further purified by silica gel chromatography (DCM: MeOH=100:0 to 20:1) to afford the title compound (3 g, 50%) as a white solid. [LCMS RtB=1.79 min, [M+H]+=387.0].

Provenance & Evidence