4-Nitrophenyl chloroformate → HCID 86730053, compound

Participants

Reaction Steps

To a solution of 6-(3-hydroxypyrrolidin-1-yl)nicotinamide (0.27 g, 1 mmol) in DCM (5 ml) was added 4-nitrophenyl carbonochloridate (0.20 g, 1 mmol). The resulting solution was stirred under N2 at room temperature for 24 h. The reaction mixture was then filtered and the filter cake was washed with DCM. The combined filtrates were concentrated to afford the title compound (0.11 g, 30%) as a yellow liquid. [LCMS RtA=1.71 min, [M+H]+=373.1].

Provenance & Evidence