4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine → 6-(4-Aminopiperidin-1-yl)nicotinamide hydrochloride

Participants

Reaction Steps

To a stirred solution of HCl/EtOAc (9 ml, 3N) was added tert-butyl 1-(5-carbamoylpyridin-2-yl)piperidin-4-ylcarbamate (400 mg) and the mixture was stirred at room temperature for 4 h. The solid was collected by filtration and washed with EtOAc to give a white solid (300 mg, 94%). [LCMS RtA=0.85 min, [M+H]+=221.1].

Provenance & Evidence