Trifluoroacetic acid → HCID 86731668, compound

Participants

Reaction Steps

To a solution of 2-{2-[(2,4-dimethoxybenzyl)amino]-6-methylpyridin-4-yl}propan-2-ol (234 mg, 0.740 mmol) in dichloromethane (5 mL) was added TFA (1 mL) at 20° C. After 2 hours, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse phase HPLC (5-50% acetonitrile/water with 0.1% TFA, linear gradient) to afford 2-(2-amino-6-methylpyridin-4-yl)propan-2-ol. MS ESI calc'd. for C9H15N2O [M+H]+ 167. found 167.

Provenance & Evidence