Bromine → 1-Bromo-6-chloro-3-hexanone

Participants

Reaction Steps

Bromine (2.0 mL, 39 mmol) was added slowly to a solution of 1-(3-chloropropyl)cyclopropanol (5.0 g, 34 mmol) in isopropanol (80% solution in water, 30 mL) at 0° C. The reaction mixture was stirred at ambient temperature for 1 hour and then was quenched with water (15 mL) and extracted with ethyl acetate (3×30 mL). The organic layers were combined, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 1-bromo-6-chlorohexan-3-one, which was used without further purification.

Provenance & Evidence