反应详情

To tert-butyl (1S,2R)-2-(6-cyano-5-(6-methyl-4-(3-methylisoxazol-4-yl)pyridin-2-ylamino)pyridin-3-ylamino)cyclohexylcarbamate (50 mg, 0.099 mmol) in DCM (1 ml) was added TFA (1.0 ml, 13 mmol). The reaction mixture was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to give 54(1R,2S)-2-aminocyclohexylamino)-3-(6-methyl-4-(3-methylisoxazol-4-yl)pyridin-2-ylamino)picolinonitrile. MS ESI calc'd. for C22H26N7O [M+H]+ 404. found 404.

1. concentrationThe reaction mixture was concentrated under reduced pressure