反应详情

To a solution of tert-butyl rel-[(3S,4S)-3-({6-cyano-5-[(4-methoxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)-1,1-dioxidotetrahydro-2H-thiopyran-4-yl]carbamate (56 mg, 0.11 mmol) in DCM (2 mL) was added TFA (1 mL). After 30 minutes, the reaction mixture was concentrated under reduced pressure to afford rel-5-{[(3S,4S)-4-amino-1,1-dioxidotetrahydro-2H-thiopyran-3-yl]amino}-3-[(4-methoxy-6-methylpyridin-2-yl)amino]pyridine-2-carbonitrile, which was used directly in the next step without purification. MS ESI calc'd. for C18H23N6O3S [M+H]+ 403. found 403.

1. concentrationthe reaction mixture was concentrated under reduced pressure