Methyl iodide → HCID 117974160, compound

Participants

Reaction Steps

N-(2-methylcyclohexyl)pyrrolidine as synthesized in Example 3 above, was quaternized with methyl iodide using the procedure described in example 4 with the exception of using N-(2-methylcyclohexyl)pyrrolidine in place of N-cyclohexylpyrrolidine. The quaternization procedure afforded the desired N-methyl-N-(2-methylcyclohexyl)pyrrolidinium iodide in 94% yield as an off-white solid. This N-methyl-N-(2-methylcyclohexyl)pyrrolidinium iodide was ion-exchanged with BIO-RAD AGR 1-X* resin as described in example 4 above. The ion-exchange procedure afforded the hydroxide solution of N-methyl-N-(2-methylcyclohexyl)pyrrolidinium cation in 91% yield as determined by titration analysis on a small aliquot.

Provenance & Evidence