Lawesson's reagent → HCID 89717812, compound

Participants

Reaction Steps

A Lawesson's reagent (50 mg, 0.12 mmol) was added to a THF (2 mL) solution of [(2,6-difluorophenylcarbamoyl)methyl]carbamic acid tert-butyl ester (52 mg, 0.18 mmol) in an argon atmosphere, and the mixture was refluxed with heating overnight. After evaporating the solvent, the residue was purified by silica gel column chromatography (13 g, hexane:acetone=10:1 to 8:1) to obtain [(2,6-difluorophenylthiocarbamoyl)methyl]carbamic acid tert-butyl ester (23 mg) as a colorless crystalline substance.

Provenance & Evidence