Methylamine → HCID 68292902, compound

Participants

Reaction Steps

To a solution of compound 37 (20 mg, 0.08 mmol) in CH3OH (3 mL) was added dropwise a solution of the CH3NH2 in CH3OH (3 mL) at 0° C. with stirring. The reaction mixture was stirred at 0° C. for 6 h. The ice-water was added into the reaction mixture. The aqueous phase was extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated to dryness to give compound 38 (25 mg) as a light yellow oil. The crude product was used directly for the next step without purification. 1H NMR (400 MHz, CDCl3) δ7.09 (d, 2H, J=8.2 Hz), 6.86 (d, 2H, J=8.2 Hz), 2.90 (t, 2H, J=7.4 Hz), 2.77 (d, 3H, J=4.8 Hz), 2.43 (t, 2H, J=7.4 Hz), 1.68 (s, 6H).

Provenance & Evidence