HCID 68292996, compound → HCID 68293341, compound

Participants

Reaction Steps

A solution of compound 123 (150 mg, 0.43 mmol) in EtOAc (10 mL) was added Pd/C (25 mg, 10%) under N2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 balloon at room temperature for 2 h. The suspension was filtered and the solid was washed by EtOAc. The filtrates were concentrated to dryness to give compound 124 (100 mg, 64%) as a light yellow oil. 1H NMR (400 MHz, CDCl3) δ7.28-7.32 (m, 1H), 6.93-6.98 (m, 1H), 6.82-6.86 (m, 1H), 6.30-6.40 (m, 2H), 3.02 (t, 2H, J=7.6 Hz), 2.63 (t, 2H, J=7.6 Hz), 1.97-2.09 (m, 2H), 1.62 (s, 9H).

Provenance & Evidence