HCID 68292797, compound → HCID 68292739, compound

Participants

Reaction Steps

A solution of the compound 134 (50 mg, 0.15 mmol) in EtOAc (10 mL) was added Pd/C (10 mg, 10%) under N2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 balloon at room temperature for 2 h. The suspension was filtered and the solid was washed by EtOAc. The filtrates were concentrated to dryness to give compound 135 (45 mg, 99%) as a light yellow oil. 1H NMR (400 MHz, CDCl3) δ8.02-8.05 (m, 1H), 7.28-7.31 (m, 1H), 6.92-7.02 (m, 2H), 6.82-6.86 (m, 1H), 3.05 (t, 2H, J=7.6 Hz), 2.81 (t, 2H, J=7.6 Hz), 2.10-2.20 (m, 2H), 1.62 (s, 9H).

Provenance & Evidence