Acetone → HCID 68292992, compound

Participants

Reaction Steps

TMSCN (3.7 mL, 27.9 mmol) was added to a mixture of the compound 139 (2.04 g, 9.3 mmol), acetone (4.1 mL, 55.8 mmol) and ZnCl2 (122 mg, 0.9 mmol) with stirring. The reaction mixture was stirred at 40° C. for 0.5 h, and concentrated in vacuo. The residue was diluted with water, and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated to dryness to give compound 140 (2.6 g, 99%) as a light yellow oil. The crude product was used directly for the next step without purification.

Provenance & Evidence