反应详情

Sodium methoxide (22.6 g) and methanol (450 mL) are charged into a 1 liter single neck round bottom flask equipped with a guard tube and stirred for few minutes to form a clear solution. A mixture of 4-octylphenethyl acetate (58 g) and methanol (50 mL) is added and the mass is stirred for 3 hours at room temperature. Methanol is evaporated and the residue is diluted with water (300 mL) and extracted with ethyl acetate (2×300 mL). The extracts are combined, dried with sodium sulphate and concentrated under vacuum to give crude as yellow color liquid. The crude is purified is by a silica gel column using 30% ethyl acetate/hexane as the eluent to yield the title compound. Yield: 56 g.

1. customequipped with a guard tube
2. customto form a clear solution
3. additionis added
4. stirringthe mass is stirred for 3 hours at room temperature
5. customMethanol is evaporated
6. additionthe residue is diluted with water (300 mL)
7. extractionextracted with ethyl acetate (2×300 mL)
8. dry with materialdried with sodium sulphate
9. concentrationconcentrated under vacuum
10. customto give crude as yellow color liquid
11. customThe crude is purified