2-Nitro-2-(4-octylphenethyl)propane-1,3-diol → Fingolimod

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Reaction Steps

2-Nitro-2-(4-octylphenethyl)propane-1,3-diol (25 g), absolute ethanol (250 mL) and 10% Pd on carbon (5 g, 50% wet) are charged into a 500 mL steel hydrogenation flask under a N2 atmosphere and the flask is equipped with a para shaker hydrogen operator. The mixture is hydrogenated with a H2 pressure of 60 psi (415 kPa) at room temperature for 2 hours and filtered through a Celite bed and washed with ethylacetate (200 mL). The filtrate is concentrated under reduced pressure at 50° C. to give the title compound as a white solid. Yield: 16 g.

Provenance & Evidence